Ketamine increases the amplitude of the 40-Hz auditory steady-state response in humans

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Ketamine increases the amplitude of the 40-Hz auditory steady-state response in humans.

The auditory middle latency response (AMLR) and the 40-Hz auditory steady-state response (40-Hz ASSR) are evoked potentials which possibly arise from the same generators in the primary auditory cortex. Both responses are attenuated by most general anaesthetics. Ketamine, however, has been reported to have no effect on the AMLR. Our aim was to evaluate the effects of ketamine on the 40-Hz ASSR. ...

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Dexamphetamine selectively increases 40 Hz auditory steady state response power to target and nontarget stimuli in healthy humans.

BACKGROUND An emerging endophenotype of schizophrenia is the reduction of both power and phase locking of the 40 Hz auditory steady state response (ASSR), and there have been a number of reports linking increased γ activity with positive psychotic symptoms. Schizophrenia and, more specifically, positive psychotic symptoms have been closely linked to increased dopamine (DA) neurophysiology. Ther...

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The effects of propofol on the 40-Hz auditory steady-state response and on the electroencephalogram in humans.

The auditory steady-state response (ASSR) is a nearly sinusoidal electrical response of the brain to auditory stimuli delivered at fast rates. The amplitude of the response is largest for stimulus rates near 40/s, hence the label 40-Hz ASSR. We have studied the effects of propofol (1.5 mg/kg) on the 40-Hz ASSR in 14 patients. The spectral edge frequency (SEF) and median frequency (MDF) of the e...

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GABAergic modulation of the 40 Hz auditory steady-state response in a rat model of schizophrenia.

Auditory steady-state auditory responses (ASSRs), in which the evoked potential entrains to stimulus frequency and phase, are reduced in magnitude in patients with schizophrenia, particularly at 40 Hz. While the neural mechanisms responsible for ASSR generation and its perturbation in schizophrenia are unknown, it has been hypothesized that the GABAA receptor subtype may have an important role....

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Frequency organization of the 40-Hz auditory steady-state response in normal hearing and in tinnitus.

We used the 40-Hz auditory steady-state response (SSR) to compare for the first time tonotopic frequency representations in the region of primary auditory cortex (PAC) between subjects with chronic tinnitus and hearing impairment and normal hearing controls. Frequency representations were measured in normal hearing (n=17) and tinnitus (n=28) subjects using eight carrier frequencies between 384 ...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1997

ISSN: 0007-0912

DOI: 10.1093/bja/78.5.524